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AKTU Immunoinformatics (BBI601) Syllabus PDF – B.Tech 3rd Year

Immunoinformatics BBI601

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  • Semester 6
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Official AKTU syllabus of Immunoinformatics (BBI601) for B.Tech 3rd Year – 4 credits, L-T-P 3-1-0. Read the unit-wise course content, course outcomes, evaluation pattern and recommended books online, or download the PDF.

Syllabus — Immunoinformatics

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BBI601 · 4 credits · L-T-P 3-1-0

Course Outcomes

At the end of the course, the student will be able to:

CO1Understand sequence analysis methods including DNA alignments, molecular evolution, viral evolution, and prediction of functions.K2
CO2Apply computational methods in immunological bioinformatics (sequence weighting, clustering, Gibbs Sampling, HMM, neural networks, microarray applications).K3
CO3Apply prediction methods for cytotoxic T cell (MHC Class I) epitopes and explain antigen processing pathways.K3
CO4Apply prediction methods for helper T cell (MHC Class II) epitopes and describe their processing mechanisms.K3
CO5Apply B cell epitope prediction approaches and web-based tools for vaccine design.K3

Course Content

L-T-P: 3-1-0

UnitTopicProposed Lecture
ISEQUENCE ANALYSIS: Alignments- DNA alignments- Molecular evolution and phylogeny- viral evolution and escape- prediction of functions.08
IIMETHODS: Methods applied in Immunological Bioinformatics-starting from sequence weighing methods to cluster analysis- Gibbs Sampling- HMM- Neural network- microarray and its applications.08
IIIMHC-I PREDICTION: Prediction of Cytotoxic T Cell (MHC Class I) Epitopes- Antigen Processing in the MHC Class I Pathway.08
IVMHC-II PREDICTION: Prediction of Helper T Cell (MHC Class II) Epitopes- Processing of MHC Class II Epitopes.08
VB CELL EPITOPE PREDICTION AND WEB SOURCES: Recognition of Antigen by B Cells- vaccine design- Web-Based Tools for Vaccine Design.08

Text Books

  1. Rammensee, “Immunoinformatics- Bioinformatics Strategies for Better Understanding of Immune Function”, Wiley, 2003.
  2. Ole Lund, “Immunological Bioinformatics”, MIT Press, September 2005.
  3. Darren Flower, “In Silico Immunology”, Springer, 2006.
  4. Darren R Flower, “Immunoinformatics: Predicting Immunogenicity in Silico”, Humana Press, 2007.

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