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AKTU Gene Therapy (BBI061) Syllabus PDF – B.Tech 3rd Year
Gene Therapy BBI061
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Official AKTU syllabus of Gene Therapy (BBI061) for B.Tech 3rd Year – 3 credits, L-T-P 3-0-0. Read the unit-wise course content, course outcomes, evaluation pattern and recommended books online, or download the PDF.
Syllabus — Gene Therapy
Download PDFBBI061 · 3 credits · L-T-P 3-0-0
Course Outcomes
At the end of the course, the student will be able to:
| CO1 | Understand general principles of gene therapy, delivery methods, and clinical trial approaches. | K2 |
| CO2 | Apply DNA-based gene therapy techniques including mechanical and liposomal delivery. | K3 |
| CO3 | Explain retroviral and adenoviral vectors, their safety, and case studies (OTC, SCID). | K2 |
| CO4 | Explain adeno-associated virus vectors, tissue-specific promoters, and targeted delivery strategies. | K2 |
| CO5 | Describe cancer gene therapy methods including prodrug activation, oncolytic viruses, DNA vaccines, and antisense approaches. | K2 |
Course Content
L-T-P: 3-0-0
| Unit | Topic | Proposed Lecture |
|---|---|---|
| I | GENERAL PRINCIPLES OF GENE THERAPY: Diseases that could be treated by gene therapy- Clinical trials- Gene Delivery. Reporter genes and Transfer efficiency- Germline vs. somatic cells- In vivo and ex vivo gene therapy- Ex vivo and In vivo Gene Therapy. | 09 |
| II | DNA–BASED GENE THERAPY: Mechanical methods of delivery- Example: Duchenne myotrophy- Liposomal methods of delivery- Cystic fibrosis. | 07 |
| III | ADENO-ASSOCIATED VIRUS-BASED VECTORS: Safety of GT vectors- Gutted vectors- Helper viruses and Packaging cell lines- Examples: ornithine transcarbamylase deficiency (OTC) - Severe Combined Immunodeficiency (SCID). -Failures in the OTC and SCID GT trials. | 08 |
| IV | EVENT HANDLINGS AND AWT CONTROLS: Hemophilia- Diabetes mellitus- Erythropoietin- How to target vector to the particular cell- Tissue specific promoters- Vectors as ligands for cellular receptors. | 08 |
| V | CANCER GENE THERAPY: Genetic Prodrug Activation Gene Therapy- GT methods to overcome chemotherapy resistance of tumors- Biological response modifiers- Oncolytic virus-based strategies of tumor treatment. DNA vaccines for cancer and infectious diseases- AIDS as a target for DNA vaccines- Antisense based methods of gene therapy. | 08 |
Text Books
- Peter J. Quesenberry, “Stem cells biology and gene therapy”, Wiley-Liss, 1998.
- Keith Greenberg, “Gene therapy”, Blackbirch Pr Inc, 2003.
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