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AKTU Metabolomics and Metabolic Engineering (BBI053) Syllabus PDF – B.Tech 3rd Year
Metabolomics and Metabolic Engineering BBI053
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Official AKTU syllabus of Metabolomics and Metabolic Engineering (BBI053) for B.Tech 3rd Year – 3 credits, L-T-P 3-0-0. Read the unit-wise course content, course outcomes, evaluation pattern and recommended books online, or download the PDF.
Syllabus — Metabolomics and Metabolic Engineering
Download PDFBBI053 · 3 credits · L-T-P 3-0-0
Course Outcomes
At the end of the course, the student will be able to:
| CO1 | Understand the role of metabolomics, analytical methods, databases, and reconstruction of metabolic networks. | K2 |
| CO2 | Apply bioinformatics tools and computational methods in metabolomics, including GC-MS pipelines and medical applications. | K3 |
| CO3 | Apply metabolic engineering principles to construct metabolic pathways. | K3 |
| CO4 | Apply metabolic flux analysis using isotope labeling, control analysis, and pathway grouping. | K3 |
| CO5 | Explain metabolic networks, kinetic models, and systems metabolic engineering approaches. | K2 |
Course Content
L-T-P: 3-0-0
| Unit | Topic | Proposed Lecture |
|---|---|---|
| I | INTRODUCTION TO METABOLOMICS: Role of metabolomics in systems biology –application of metabolomics- Analytical methods in metabolomics – Data standards– Databases for Chemical, Spectral and Biological Data –Reconstruction of dynamic metabolic network model- examples- study of metabolome of a simple organism like E. Coli. | 08 |
| II | BIOINFORMATICS IN METABOLOMICS: Online databases and pipelines for metabolomics – GC-MS based metabolomics – Computational methods to compute and integrate metabolic data software for metabolomics- metabolomics and medical sciences. | 08 |
| III | INTRODUCTION TO METABOLIC ENGINEERING: Importance of metabolic engineering- comprehensive models for cellular reactions-material balances & data consistency- metabolic pathway synthesis. | 08 |
| IV | METABOLIC FLUX ANALYSIS AND ITS APPLICATION: Theory-determination of flux by isotope labeling-Metabolic control analysis- (control coefficients and summation theorems, FCC determination)-Grouping of reactions (gFCC, identification of independent pathways). | 08 |
| V | METABOLIC NETWORKS: Kinetic model of metabolic networks- Systems metabolic engineering of E. coli- bottom up and top down approaches of network analysis. | 08 |
Text Books
- Silas G. Villas-Boas, Jens Nielsen, Jorn Smedsgaard, Michael A. E. Hansen, Ute Roessner-Tunali, “Metabolome Analysis: An Introduction”, John Wiley & Sons, 2007.
- Jens Høiriis Nielsen, Michael C. Jewett, “Metabolomics: A Powerful Tool in Systems Biology”, Springer, 2007.
- Dr. Christoph Wittmann, Sang Yup Lee, “Systems Metabolic Engineering”, Springer, 2012.
- Gregory N. Stephanopoulos, “Metabolic Engineering- Principles and Methodologies”, Academic Press, First Edition, 1998.
- Ute Roessner, “Metabolomics”, InTech, 2012.
- Wolfram Weckwerth, “Metabolomics: Methods and Protocols”, Humana Press, 2007.
- Cortassa S., “An Introduction to Metabolic and Cellular Engineering”, World Scientific Publishing Company Ltd., 2002.
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