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AKTU Biophysics (BBI055) Syllabus PDF – B.Tech 3rd Year
Biophysics BBI055
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Official AKTU syllabus of Biophysics (BBI055) for B.Tech 3rd Year – 3 credits, L-T-P 3-0-0. Read the unit-wise course content, course outcomes, evaluation pattern and recommended books online, or download the PDF.
Syllabus — Biophysics
Download PDFBBI055 · 3 credits · L-T-P 3-0-0
Course Outcomes
At the end of the course, the student will be able to:
| CO1 | Understand fundamental principles of biophysics including atomic interactions, mechanics, and thermodynamics. | K2 |
| CO2 | Apply DNA biophysics concepts such as structural forms, torsion angles, and helical parameters. | K3 |
| CO3 | Explain protein biophysics including peptide bonds, Ramachandran plots, and biomolecular interactions. | K2 |
| CO4 | Explain carbohydrate biophysics covering monosaccharides, polysaccharides, and conjugates. | K2 |
| CO5 | Apply X-ray crystallography, NMR, spectroscopy, Mass Spectrometry, and MALDI-TOF techniques to study biomolecules. | K3 |
Course Content
L-T-P: 3-0-0
| Unit | Topic | Proposed Lecture |
|---|---|---|
| I | ELEMENTARY BIOPHYSICS RESEARCH: Definition of atom and its properties, size and charge of electron, nucleus, protons & neutrons. Types of interaction between atoms: Bond distance, Bond angle, Torsion Angle, H-bonding, VdW interactions, Hydrophobic interactions, Electrostatics interactions. Classical Mechanics: Newton’s laws of motion, Law of conservation of mass and energy. Thermodynamics: Laws, Enthalpy, Entropy, Free Energy, Gibbs & Helmholtz free energy, Internal energy. | 08 |
| II | DNA BIOPHYSICS: Structure of A, B & Z forms of DNA with special emphasize to formation of phosphodiester bond, hydrogen bonding between the two strands of DNA, Helical parameters, DNA Backbone torsion angles, sugar back bone torsion angles, pseudo rotation, sugar puckering. Comparison of various parameters of A, B & Z forms of DNA. | 08 |
| III | PROTEIN BIOPHYSICS: Amino acids, peptide bond, phi, psi & omega angles with distance, Zwitterion formation of amino acids, Levels of protein structure, Significance of Ramachandran Plot, Protein – DNA, drug, carbohydrate, small molecule interactions. Energetics of lipid bilayer. Molecular Mechanics & Dynamics protocol. | 08 |
| IV | CARBOHYDRATE BIOPHYSICS: Structure of D-glucose & D-fructose; formation of glucosides & the cyclic structure of D-glucose; D-ribose & D-deoxyribose; Structure and conformation of disaccharides and polysaccharides-cellulose, amylose, amylopectin & glycogen, Chitin, carbohydrate conjugates. | 08 |
| V | TECHNIQUES IN BIOPHYSICS: X-ray crystallography, NMR, IR, Raman, AAS, UV, CD, Cosy, Noesy, spectroscopy, Mass spectrometry, Maldi TOF for protein prediction. | 08 |
Text Books
- Carl Branden & John Tooze (1999), “Introduction to Protein Structure”, Garland Publishing, New York & London.
- Wolfram Saenger (1983), “Principles of Nucleic Acid Structure”, Springer- Verlag, New York.
- Andrew R. Leach (2000), “Molecular Modelling Principles and Applications”, Prentice Hall.
- Puri B.R., L.R. Sharma, M.S. Pathania (2008), “Principles of Physical Chemistry”, Vishal Publishing Company.
- Murugesan R. (2004), “Modern Physics”, S. Chand & Co.
- Vasantha Pattabhi & Gautham (2002), “Biophysics”, Narosa Publishing.
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