FREE
AKTU Bioprocess Engineering II (BBT601) Syllabus PDF – B.Tech 3rd Year
Bioprocess Engineering II BBT601
All syllabus, notes, question bank & PYQ for this subject
Free
Download now
- English
- Semester 6
- 0 downloads
- 0 views
Official AKTU syllabus of Bioprocess Engineering II (BBT601) for B.Tech 3rd Year – 3 credits, L-T-P 3-0-0. Read the unit-wise course content, course outcomes, evaluation pattern and recommended books online, or download the PDF.
Syllabus — Bioprocess Engineering II
Download PDFBBT601 · 3 credits · L-T-P 3-0-0
EXAM DURATION: 3 Hours SEMESTER: VI (EVEN) L: T: P :: 3 : 0 : 0 CREDITS: 3 PREREQUISITE: Basic Knowledge of Fermentation Biotechnology, Bioprocess Engineering I and Microbiology
Course Objectives
- To impart knowledge on fundamentals of stoichiometry of reactions used in bioreactor operations.
- To explain the principles of bioreactors and their application to upstream and downstream processing.
- To impart knowledge of different kinetics models applied for Batch, CSTR, PFR and other types of reactors.
- To describe the different downstream processing, product fractionation and polishing techniques. Course Outcomes (Six): On completion of this course, the students will be able to:
- Perform unit conversions; solve material and energy balance problems in unit operations.
- Analyze the stoichiometry of cell growth and product formation.
- Learn about classification and kinetics of reactions, elementary and non-elementary reactions.
- Kinetic analysis of batch reactor, CSTRS and Plug flow reactor data.
- Recognize the basis for various steps in downstream processing design strategy for purification of a product.
- Learn techniques such as precipitation, membrane separation and chromatographic techniques for the purification of a targeted protein(s) or any other biological material. CO-PO Mapping (1 to 3 scale)
| CO/PO | PO-1 | PO-2 PO-3 PO-4 PO-5 PO-6 PO-7 PO-8 PO-9 PO- 10 PO- 11 PO- 12 |
| CO-1 | 2 | 1 |
| CO-2 | 2 | 1 |
| CO-3 | 2 | |
| CO-4 | 1 | 2 |
| CO-5 | 2 | 1 2 |
| CO-6 | 2 | 1 2 |
Reference Books
| S. No. | Name Of Authors/Books/Publishers | Year of Publication/ Reprint |
| 1. | K.V. Narayanan and B. Lakshmikuttyamma, Stoichiometry & Process Calculations, Prentice Hall Publishing, Delhi. | 2006 |
| 2. | B.I. Bhatt and S. M. Vora, Stoichiometry, 4th Edn., Tata McGraw-Hill Publishing Company Ltd., New Delhi. | 2001 |
| 3. | M. L. Shuler and F. Kargi, Bioprocess Engineering-Basic Concepts, 2nd Edn., Prentice Hall. | 2004 |
| 4. | P. M. Doran, Bioprocess Engineering Principles, 2nd Edn, Academic Press. | 2005 |
| 5. | N. K. Prasad, Downstream Process Technology - A New Horizon in Biotechnology”, Prentice Hall of India, New Delhi. | 2012 |
| 6. | M. R. Ladisch, Bioseparations Engineering: Principles, Practice and Economics, 1st Edn., Wiley Interscience. | 2001 |
| 7. | J. D. Seader and E.J. Henley, Separation Process Principles, 3rd Edn., Wiley. | 2010 |
| 8. | Sivasankar B, Bioseparations: Principles and Techniques, Prentice-Hall of India Pvt. Ltd. | 2008 |
| 9. | P. A. Belter, E. L. Cussler, and W.S. Hu, Bioseparation: Downstream Processing for Biotechnology, 2nd Edn., Wiley- Interscience. | 1994 |
Course Details
| COURSE DETAILS: BIOPROCESS ENGINEERING II | ||
| Unit | Content | Contact Hours |
| I | Stoichiometry of Bioprocesses: Material and Energy Balance Introduction to conversion of units, Dimensionless groups applied in bioprocess, graphical differentiation and integration, material balance equation for steady and unsteady state, simplifications for steady-state processes with and without chemical reaction, stoichiometry of cell growth and product formation, degrees of reduction of substrate and biomass, yield coefficients of biomass and product formation, maintenance coefficients, oxygen consumption and heat evolution in aerobic cultures. Energy balance - heat capacity, estimation of heat capacities, general energy balance, Enthalpy calculation, enthalpy change: heat of combustion, heat of reaction for biomass production processes, energy-balance equation for cell culture and fermentation processes. | 13 |
| II | Kinetics of homogenous reactions: classification of reactions, reaction rate, speed of reaction, rate equation, concentration-dependent term of rate equation, rate constant, order and molecularity, representation of elementary and non-elementary reactions, Kinetic models for non-elementary reactions, temperature dependent term of a rate equation, activation energy and temperature dependency. | 10 |
| III | Kinetic analysis of batch reactor data: Integral and differential methods for analyzing kinetic data, interpretation of constant volume batch reactor, data for zero, first, second and third order reactions, half-life period, irreversible reaction in parallel and series, auto catalytic reactions. Kinetic interpretation of batch reactor data for single reactions, interpretation of variable volume batch reaction data for zero, first, second and third order reactions, Ideal batch reactor, steady state CSTR and plug flow reactors and their use for kinetic interpretation. Design for single reaction: size comparison of single reactors, plug flow reaction in series and/or parallel, equal and different size of mixed reactor in series, finding the best system | 10 |
| of given conversion, recycle reactor, Design of multiple reactions in batch, CSTR and PFR. | ||
| IV | Downstream Processing Introduction to the various downstream processing steps and their significance in biotechnology, Cell disruption; cell separation, Centrifugation and Filtration: Flocculation, and sedimentation. Extraction: Basic equations of extraction, Aqueous two-phase extraction, batch extraction, staged extraction and differential extraction, Supercritical fluid extraction; Adsorption and Leaching, Precipitation; Membrane-based purification: Reverse osmosis, Dialysis. | 8 |
| V | Product Resolution / Fractionation and Polishing General chromatography theory and the different chromatographic techniques like adsorption, partition, ion exchange, affinity, gel filtration and HPLC, Dialysis, Crystallization, and Drying. Any Emerging Technologies in downstream processing in biotechnology industries. 49 | 8 |
Ratings & Reviews
No reviews yet — share your experience with this item.