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AKTU Biomarker & Diagnostics (BBT062) Syllabus PDF – B.Tech 3rd Year
Biomarker & Diagnostics BBT062
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Official AKTU syllabus of Biomarker & Diagnostics (BBT062) for B.Tech 3rd Year – 3 credits, L-T-P 3-0-0. Read the unit-wise course content, course outcomes, evaluation pattern and recommended books online, or download the PDF.
Syllabus — Biomarker & Diagnostics
Download PDFBBT062 · 3 credits · L-T-P 3-0-0
EXAM DURATION: 3 Hours SEMESTER: VI (EVEN) L: T: P :: 3 : 0 : 0 CREDITS: 3 PREREQUISITE: Basic Knowledge of Molecular Biology, Immunology and Analytical Techniques
Course Objectives
- To introduce basics of molecular diagnostics, its scope and applications
- To learn various pathways of cell signaling, eukaryotic cell control system and their components
- To learn different molecular mechanisms of generation of metabolic disorders
- To elaborate various applications of biomarkers in disease diagnostics
- To understand advanced molecular techniques: FISH, CGH, flow cytometry, genome mapping methodology Course Outcomes (Six): On completion of this course, the students will be able to:
- Understand the history and basics of Molecular Diagnostics.
- Understand importance of biomarkers in molecular diagnostics
- Understand molecular oncology with specific emphasis on cancer and its relevant cause
- Learn principles and applications of some of advanced molecular diagnostic techniques
- Learn about the different types of molecular markers, their role in diagnostics.
- Understand the basics of chromosome related disorders, techniques like FISH, cytometry and others used in diagnostics. CO-PO Mapping (1 to 3 scale)
| CO/PO | PO-1 | PO-2 | PO-3 | PO-4 PO-5 PO-6 PO-7 PO-8 PO-9 PO- 10 PO- 11 PO- 12 |
| CO-1 | 1 | 3 | ||
| CO-2 | 2 | 1 | 2 | 1 |
| CO-3 | 2 | 1 | 2 | 1 |
| CO-4 | 2 | 1 | 2 | |
| CO-5 | 2 | 1 | 2 | 1 |
| CO-6 | 2 | 1 |
Reference Books
| S. No. | Name Of Authors/Books/Publishers |
| 1. | Molecular biology of the cell. Bruce Alberts, 6th Edition |
| 2. | Principles of Tissue Engineering. Robert Lanza. Elsevier Publications |
| 3. | Introduction to Tissue Engineering, Applications and Challenges. Ravi Birla. Wiley Publications |
| 4. | Molecular Cell Biology: Darnell J, Lodish H and Baltimore D |
| 5. | Cell and Molecular Biology: De Robertis EDP and De Robertis EMF |
| 6. | An Introduction to Human Molecular Genetics by Pasternak et al., John Wiley & Sons |
| 7. | Human Chromosomes by Miller & Tharman, Springer Publishing Company |
| 8. | Molecular Biology of the Cell by Alberts et al., Garland Press |
Year of Publication/ Reprint 2014 2000 2014 1990 1980 2005 2001 2008
| 9. | Genes IX, by Lewin B, Pearson India |
| 10. | Cell and Molecular Biology by De Robertis and De Robertis, Lipincott & Wilkins |
| 11. | Genome III by TA Brown, Garland Press |
| 12. | Elements of Medical Genetics by Turnpenny and Ellard, Churchill Livingstone |
| 13. | Animal Cell Culture: Ian Freshney |
2007 2007 2006 1995 2015
| COURSE DETAILS: BIOMARKER & DIAGNOSTICS | ||
| Unit | Content | Contact Hours |
| I | Introduction to Molecular Diagnostics: History of diagnostics, Age of molecular diagnostics, Significance, Scope, Rise of diagnostic industry in Indian and global scenario, Cellular Complexity: Cell components, Cell Differentiation, Cellular communication – endocrine signaling, paracrine signaling and autocrine signaling, contact dependent and synaptic communications, Intracellular networks – transport pathways, signaling pathways and metabolic networks. Eukaryotic Cell Control System and their Components, Intracellular cell cycle control system, Extracellular Cell Cycle Control System, Regulation of Cell Growth and Apoptosis, Genetic and epigenetic factors that regulate these pathways, their abnormalities that alter the pathways and cellular functions. | 12 |
| II | Molecular Oncology Mitochondrial disorders: Cancer – Benign and Malignant neoplasms, multifactorial disposition, Cancer pathogenesis, positive and negative mediators of neoplastic development, Proto-oncogenes, Oncogenes and Tumor suppressors. Allele loss and loss of Heterozygosity. Mitochondrial inheritance, Mitochondrial myopathy, lactic acidosis, MELAS, LHONs, identity testing | 8 |
| III | Biomarkers in disease diagnostics: FDA definition of disease markers, Role of markers in Disease diagnosis. Approaches and methods in the identification of disease markers, predictive value, diagnostic value, emerging blood markers for sepsis, tumor & cancer markers, markers in inflammation and diagnosis of cytoskeletal disorders | 6 |
| IV | Chromosomes, Human disorders, and Cytogenetic analysis: Structure, types and organization; Chromosome organization, Euchromatin and heterochromatin and Histone modifications. Chromosome banding and nomenclature; Nomenclature and functional significances of chromosome bands. GC and AT rich isochores. Structural and Numerical aberrations and its consequences. X-chromosome dosage compensation and inactivation mechanism. Sex determination and Y chromosome; function, and diseases. Uniparentaldisomy, Genomic Imprinting and disorders. FISH, CGH, Flow cytometry techniques and clinical diagnostics. | 10 |
| V | Genomic instability, Chromosome mapping & Genome plasticity: Common fragile sites and methods of induction, Heritable fragile sites and FXS. Genomic Instability, mechanism and diseases. Trinucleotide Repeats; Mechanism of expansion and triplet repeats and related disorders. Genetic linkage maps, Relation to the probability of recombination, Pedigree analysis with genetic markers and overview of human genome project 46 | 10 |
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