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AKTU Metabolic Engineering (BBT054) Syllabus PDF – B.Tech 3rd Year
Metabolic Engineering BBT054
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Official AKTU syllabus of Metabolic Engineering (BBT054) for B.Tech 3rd Year – 3 credits, L-T-P 3-0-0. Read the unit-wise course content, course outcomes, evaluation pattern and recommended books online, or download the PDF.
Syllabus — Metabolic Engineering
Download PDFBBT054 · 3 credits · L-T-P 3-0-0
Course Objectives
To teach the concept and application of metabolic engineering To develop understanding metabolites production in different pathways and regulatory mechanism.
To provide knowledge biosynthesis of metabolites To teach the bioconversions, product inhibition and factors affecting bioconversions.
COURSE OUTCOMES (SIX): Upon completion of this course, the students will be able to:
| CO1 | Explain basic concepts of metabolism and importance of metabolic engineering |
| CO2 | Understand the production of metabolites and its regulatory mechanism |
| CO3 | Explain the applications, specificity and product inhibition of bioconversion. |
| CO4 | Regulation of enzyme production and strain improvement |
| CO5 | Understand the general principles of intermediary metabolism, including the regulation of metabolic pathways at both the enzyme and cellular levels. |
| CO6 | Explore mixed or sequential bioconversions and the conversion of insoluble substances. |
CO-PO MAPPING (1 TO 3 SCALE)
| CO/PO | PO-1 | PO-2 | PO-3 | PO-4 | PO-5 | PO-6 | PO-7 PO-8 PO-9 PO- 10 PO- 11 PO- 12 |
| CO-1 | 1 | 2 | 1 | 2 | 3 | 1 | 2 |
| CO-2 | 1 | 2 | 1 | 2 | 1 | 2 | 1 |
| CO-3 | 1 | 2 | 1 | 2 | 1 | 2 | 1 |
| CO-4 | 1 | 2 | 1 | 3 | 1 | ||
| CO-5 | 1 | 2 | 1 | 2 | 1 | ||
| CO-6 | 1 | 2 | 1 | 2 | 1 |
Reference Books
- G. Stephanopoulos, A. Aristidou and J. Nielsen, Metabolic Engineering Principles and Methodologies, Academic Press, 1998
- Daniel I. C. Wang, Malcolm D. Lilly, Arthur E. Humphrey, Peter Dunnill, Arnold l.Demain, Fermentation and Enzyme Technology,1st edition John Wiley& Sons, Reprint, 2005
- Christina Smolke, The Metabolic Pathway Engineering Handbook (Two Volume) Set 1st edition CRC press, 2009.
- Stanbury P. F. and Whitaker A., Principles of Fermentation Technology, Pergamon Press,1984.
| COURSE DETAILS: METABOLIC ENGINEERING | ||
| Unit | Content | Contact Hours |
| I | Basic concept of metabolism, anabolism & catabolism, Importance of metabolic e ngineering, General Principles of Intermediary Metabolism, Regulation of Pathways, Strategies for Pathway Analysis. Understanding the role of Bioinformatics in the study of me tabolic pathways | 6 |
| II | Synthesis of primary metabolites: Amino acid synthesis pathways and its regulation at enzyme level and whole cell level, Alteration of feedback regulation, Limiting accumulation of end products | 8 |
| III | Biosynthesis of secondary metabolites: Regulation of secondary metabolite pathways, precursor effects, prophase, idiophase relationship, producers of secondary metabolites, applications of secondary metabolites. | 12 |
| IV | Bioconversions: Applications of Bioconversions, Factors affecting bioconversions, Specificity, Yields, Product inhibition, mixed or sequential bioconversions, Conversion of insoluble substances | 7 |
| V | Regulation of enzyme production: Strain selection, Genetic improvement of strains, Gene dosage, metabolic pathway manipulations to improve fermentation, Feedback repression, Catabolite Repression, optimization and control of metabolic activities. | 09 |
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