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AKTU Systemic Pharmacology I (Practical) (BP410P) Syllabus PDF – B.Pharm 4th Semester
Systemic Pharmacology I (Practical) BP410P
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Official AKTU syllabus of Systemic Pharmacology I (Practical) (BP410P) for B.Pharm 4th Semester – 1 credits, L-T-P 0-0-3. Read the unit-wise course content, course outcomes, evaluation pattern and recommended books online, or download the PDF.
Syllabus — Systemic Pharmacology I (Practical)
Download PDFBP410P · 1 credits · L-T-P 0-0-3
Course Objectives
- Provide understanding of the theoretical and practical aspects of different pharmacological experiments using virtual simulations and video demonstrations.
- Develop skills to assess drug effects on various systems such as cardiovascular, respiratory, skeletal muscle, and gastrointestinal tract using simulation models. 3. preparation, spasmogen and spasmolytic effects, and PA2 value determination using Schild plot.
- Provide knowledge of modern techniques for drug evaluation.
- Explore clinical pharmacology aspects through case studies on drug interactions, management of cardiovascular and respiratory diseases, and plasma volume expanders.
Course Outcomes
| CO | Upon successful completion of this course, the students will be able to: |
| No. | |
| 1 | Describe the drug effects on blood pressure, heart rate, and understand their relevance to cardiovascular pharmacotherapy through virtual simulations. |
| 2 | Evaluate the pharmacological management of asthma, analyse drug actions on the respiratory system, and correlate them with clinical data. |
| 3 | Interpret experimental data, calculate and analyse PA2 values, plot standard curves, and estimate drug effects using hypothetical data from computer simulations. |
| 4 | Present case studies and explore drug interactions and rational drug management in cardiovascular situations and asthma, applying pharmacological knowledge to patient care. |
| 5 | Demonstrate competence in various pharmacological measurements, such as intraocular pressure estimation, nitric oxide estimation in plasma, and spirometry. |
Course Content
List of practical (Minimum 12 Experiments must be performed)
- To demonstrate Langendorff’s heart assembly and its application in pharmacology (only video demonstration/or charts and illustrations).
- Recording of the effects of different electrolytes, agonists and antagonists on the isolated and perfused frog heart preparation using interactive computer simulation experiment.
- To study the effect of various drugs on blood pressure and heart rate anaesthetized dog using interactive computer simulation experiment.
- Demonstration of the estimation of intraocular pressure on rabbit eye and human eye by using conventional Schiotz tonometer and non-contact tonometer.
- To evaluate the muscle relaxant activity of drugs on Rota-rod apparatus using interactive computer simulation experiment.
- Demonstration of the effect of spasmogens and spasmolytic using rabbit jejunum using interactive computer simulation experiment.
- Determination of PA2 value of Atropine using a suitable isolated tissue preparation by Schild plot plot method with the help of hypothetical data using interactive computer simulation experiment.
- Determination of PA2 value of Prazosin using a suitable isolated tissue preparation by Schild method with the help of hypothetical data using interactive computer simulation experiment.
- To study the antiallergic effects of drugs using mast cell degranulation assay using interactive computer simulated experiment
- Evaluation of diuretic activity of drugs in rats using metabolic cages (simulation) and estimation of electrolytes in the urine samples/serum using flame photometer/commercially available kits.
- Evaluation of effects of antihistaminic drugs on the histamine-induced bronchospasm in guinea pigs using interactive simulated experiment.
- To study and analyse drug-drug interaction/ rational drug management of asthma with the help of Case Study/ hypothetical data/ any clinical report.
- To study clinical pharmacology of the plasma volume expanders and their importance (using charts/open sources videos).
- Demonstration of evaluation of anti-inflammatory activity in paw oedema model using plethysmometer using simulations.
- Concept of Biobanking and its significance in drug screening.
- Isolation of Polymorphonuclear cells from blood and evaluation of endotoxin-induced oxidative stress in them using Nitrobluetetrazolium dye method by colourimetry.
- Determination of viability of cells (using isolated polymorphonuclear cells) by Trypan blue dye exclusion assay to determine cell viability using microscopy method.
- Determination of anti-inflammatory activity of durgs in vitro using RBC membrane stabilization assay
- Determination of protein concentrations using Bradford reagent and plotting of standard curve of bovine serum albumin.
- Estimation of anticholinesterase inhibitory activity of drugs using Ellman’s reagent (DTNB)
- Determination and and plotting of standard curve for LPO, Nitric oxide and GSH.
Recommended References
- Ghosh, M. N. Fundamentals of Experimental Pharmacology. Hilton & Company.
- Goyal, R. K. Practical Pharmacology. B. S. Shah Prakashan.
- Kulkarni, S. K. Handbook of Experimental Pharmacology. Vallabh Prakashan.
- Computer Assisted Learning (CAL) software packages for experimental pharmacology simulations.
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