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AKTU Medicinal Chemistry (Theory) (BP402T) Syllabus PDF – B.Pharm 4th Semester
Medicinal Chemistry (Theory) BP402T
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Official AKTU syllabus of Medicinal Chemistry (Theory) (BP402T) for B.Pharm 4th Semester – 3 credits, L-T-P 3-0-0. Read the unit-wise course content, course outcomes, evaluation pattern and recommended books online, or download the PDF.
Syllabus — Medicinal Chemistry (Theory)
Download PDFBP402T · 3 credits · L-T-P 3-0-0
Course Objectives
- Develop a comprehensive understanding of the fundamental principles of medicinal chemistry, including physicochemical properties, drug metabolism, and prodrug concepts.
- Classify and describe the chemical structures, therapeutic uses, and structure activity relationships of drugs acting on the autonomic and cardiovascular systems.
- Apply the principles of structure activity relationships (SAR) to explain and predict the pharmacological activity.
- Understand the synthetic pathways of drugs, emphasizing important reaction steps and chemical transformations.
- Analyze the relationship between drug structure and pharmacological activity in relation to therapeutic efficacy and safety.
Course Outcomes
| CO | Upon successful completion of this course, the students will be able to: |
| No. | |
| 1 | Relate the physicochemical properties of drug molecules to their biological activity and pharmacokinetic behavior. |
| 2 | Categorize drugs affecting the autonomic nervous system and predict their therapeutic outcomes. |
| 3 | Analyze and interpret the structure-activity relationships of selected drug classes (e.g., beta-blockers, local anesthetics, thiazide diuretics, NSAIDs) to optimize drug design. |
| 4 | Outline the synthetic routes of selected drugs, identifying key intermediates and reactions involved in their preparation. |
| 5 | Correlate the chemical structure of drugs with their therapeutic uses and potential adverse effects. Apply the knowledge of medicinal chemistry principles to understand and potentially contribute to the drug discovery and development process. |
Course Content
| Unit | Topics | No. of |
|---|---|---|
| No. | Lectures Study of the development of the following classes of drugs, Chemical Classification, Structure, uses of drugs mentioned in the course, Structure activity relationship of selective class of drugs as specified in the course and Synthesis of selected drugs as superscripted (*) | |
| I | Fundamentals of Medicinal Chemistry Introduction: History and scope of medicinal chemistry Physicochemical properties in relation to biological action: Ionization, solubility, partition coefficient, hydrogen bonding, Chelation, Bioisosterism and protein binding Drug metabolism: Phase I & II reactions | 7 hours |
| II | Drugs Acting on the Autonomic Nervous System 1. Adrenergic or Sympathomimetic agents: Nor-epinephrine, Epinephrine, Phenylephrine*, Dopamine, Methyldopa, Clonidine, Dobutamine, Isoproterenol, Terbutaline, Salbutamol*, Bitolterol, Naphazoline, Oxymetazoline and Xylometazoline, Hydroxyamphetamine, Pseudoephedrine, Propylhexedrine, Metaraminol. 2. Anti-adrenergic or Sympatholytic agents: Tolazoline*, Phentolamine, Phenoxybenzamine, Prazosin, Dihydroergotamine, Propranolol*, Metibranolol, Atenolol, Betazolol, Bisoprolol, Esmolol, Metoprolol, Labetalol, Carvedilol. SAR of beta adrenergic blockers. 3. Cholinergic or Parasympathomimetic agents: Acetylcholine, Carbachol*, Bethanechol, Methacholine, Pilocarpine, Physostigmine, Neostigmine, Pyridostigmine, Edrophonium chloride, Tacrine hydrochloride, Ambenonium chloride, Isofluorphate, Echothiophate iodide, Parathione, Malathion. Pralidoxime chloride. 4. Anti-Cholinergic or Parasympatholytic agents: Atropine, Hyoscyamine, Scopolamine, Homatropine, Ipratropium*, Tropicamide, Cyclopentolate, Clidinium Glycopyrrolate, Dicyclomine*, Methantheline, Propantheline, Benztropine mesylate, Orphenadrine, Biperidine, Procyclidine, Tridihexethyl, Isopropamide, Ethopropazine, SAR of cholinergic blockers. 5. Local anesthetic agents: Cocaine, Hexylcaine, Meprylcaine, Cyclomethycaine, Piperocaine. Benzocaine, Butamben, Procaine*, Butacaine, Propoxycaine, Tetracaine, Benoxinate, Lignocaine, Mepivacaine, Prilocaine, Etidocaine, Phenacaine, Diperodon, Dibucaine.* SAR of Local anesthetics. | 15 hours |
| III | Drugs Acting on the Cardiovascular System 1. Anti-anginals: Amyl nitrite, Nitroglycerin, Pentaerythritol, Isosorbide dinitrite*, Dipyridamole, Verapamil, Bepridil | 09 hours |
hydrochloride, Diltiazem, Nifedipine, Amlodipine, Felodipine, Nicardipine, Nimodipine.
- Anti-hypertensives: Timolol, Captopril, Lisinopril, Enalapril, Benazepril, Quinapril, Methyldopate,* Clonidine, Guanethidine, Guanabenz, Sodium nitroprusside, Diazoxide, Minoxidil, Reserpine, Hydralazine.
- Drugs to treat Congestive Heart Failure (CHF): Digoxin, Digitoxin, Nesiritide, Bosentan,Tezosentan.
- Anti-arrhythmics (Class I IV): Quinidine sulphate, Procainamide, Disopyramide*, Phenytoin, Lidocaine, Tocainide, Mexiletine, Lorcainide, Amiodarone, Sotalol.
| IV | Drugs acting on blood and Renal System 1. Antihyperlipidemic Agents: Fenofibrate*, Lovastatin, Cholesteramine and Cholestipol 2. Coagulants and Anti-Coagulants: Menadione, Acetomenadione, Warfarin, Anisindione, clopidogrel. 3. Diuretics: Acetazolamide*, Methazolamide, Dichlorphenamide, Chlorthiazide, Hydrochlorothiazide, Hydroflumethiazide, Cyclothiazide, Furosemide*, Bumetanide, Ethacrynic acid, Spironolactone, Triamterene, Amiloride. Mannitol. SAR of Thiazides. | 06 hours |
| V | Autacoids and related drugs 1. Antihistamines a. H1 antagonists: Diphenhydramine hydrochloride*, Dimenhydrinate, Doxylamines, Clemastine, Diphenylphyraline, Tripelenamine, Chlorcyclizine, Meclizine, Buclizine, Chlorpheniramine, Triprolidine, Phenindamine, Promethazine*, Trimeprazine, Cyproheptadine, Azatidine, Astemizole, Loratadine, Cetirizine, Levocetrizine Cromolyn. b. H2-antagonists: Cimetidine*, Famotidine, Ranitidine. 2. Gastric Proton pump inhibitors: Omeprazole, Lansoprazole, Rabeprazole, Pantoprazole Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Antipyretics: Sodium salicylate, Aspirin, Diflunisal, Mefenamic acid*, Niflumic acid, Meclofenamate, Indomethacin, Sulindac, Tolmetin, Zomepirac, Diclofenac, Ketorolac, Ibuprofen*, Naproxen, Piroxicam, Phenacetin, Acetaminophen, Antipyrine, Phenylbutazone, Celecoxib, Etoricoxib, SAR of representative agents by class. | 08 hours |
Recommended References
- Lemke, T. L., Williams, D. A. and Roche, V. F. Chemistry. Lippincott Williams & Wilkins.
- Beale, J. M., Thomas, J. T. and Duckett, M. H. Organic Medicinal and Pharmaceutical Chemistry. Lippincott Williams & Wilkins.
- Abraham, D. J. and Griffin, J. L. Discovery. Wiley.
- Patrick, G. L. An Introduction to Medicinal Chemistry. Oxford University Press.
- Kar, A. Medicinal Chemistry. New Age International.
- Li, J. J. and Welch, W. M. Modern Drug Synthesis. Wiley.
- Lednicer, D. The Organic Chemistry of Drug Synthesis. Wiley.
- Furniss, B. S., Hannaford, A. J., Smith, P. W. G. and Tatchell, A. R. Textbook of Practical Organic Chemistry. Pearson Education.
- Brunton, L., Hilal-Dandan, R. and Knollmann, B. Pharmacological Basis of Therapeutics. McGraw-Hill Education. 10. Wilkins.
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