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AKTU Pharmaceutical Biotechnology (Theory) (BP403T) Syllabus PDF – B.Pharm 4th Semester
Pharmaceutical Biotechnology (Theory) BP403T
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Official AKTU syllabus of Pharmaceutical Biotechnology (Theory) (BP403T) for B.Pharm 4th Semester – 3 credits, L-T-P 3-0-0. Read the unit-wise course content, course outcomes, evaluation pattern and recommended books online, or download the PDF.
Syllabus — Pharmaceutical Biotechnology (Theory)
Download PDFBP403T · 3 credits · L-T-P 3-0-0
Course Objectives
- Understand and apply plant tissue culture techniques and related approaches for biomass and secondary metabolite production.
- Introduce biomanufacturing concepts in herbal drug technology, including plant-based production systems and edible vaccines.
- Develop skills in the preparation and optimization of standardized herbal extracts using metabolite analysis and TLC fingerprinting.
- Study the formulation of herbal products using standardized extracts in conventional and novel dosage forms.
- Understand quality control, standardization, regulatory guidelines, and interaction studies for safe herbal drug development.
Course Outcomes
| CO | Upon successful completion of this course, the students will be able to: |
| No. | |
| 1 | Explain the role of biotechnology in pharmaceutical sciences, including monoclonal antibodies and enzyme immobilization. |
| 2 | Apply genetic engineering and recombinant DNA technology for the production of biopharmaceuticals such as insulin, interferons, and vaccines. |
| 3 | Describe microbial biotransformation and analyze fermentation processes used in pharmaceutical industries. |
| 4 | Assess the role of bioinformatics and artificial intelligence in the Human Genome Project and personalized medicine. |
| 5 | Describe vaccine and sera development, including preparation, evaluation, standardization, and regulatory requirements, and critically evaluate challenges and emerging approaches in vaccine and sera development and commercialization |
Course Content
| Unit | Topics | No. of |
|---|---|---|
| I | Introduction to Pharmaceutical Biotechnology Introduction to biotechnology in pharmaceutical sciences; protein therapeutics; analytical characterization of proteins; monoclonal antibodies; antigens; enzyme immobilization; cell culture and immobilization techniques; pharmaceutical applications. | 9 Hours |
| II | Genetic Engineering and Recombinant DNA Technology Principles of genetic engineering; recombinant DNA technology; production of interferons, hepatitis-B vaccine, and insulin; polymerase chain reaction (PCR) and its applications; mutations and types of mutants. | 9 Hours |
| III | Microbial Biotransformation and Fermentation Technology Microbial biotransformation; fermentation principles and process control; blood products collection, processing, and storage. | 9 Hours |
| IV | Gene Therapy, Genomics and Personalized Medicine Gene therapy types and methodologies; delivery systems; ethical concerns and challenges; Human Genome Project; role of bioinformatics and artificial intelligence in personalized medicine. | 9 Hours |
| V | Immunology, Vaccines and Sera Basics of immunology; types and generations of vaccines; immunization strategies; vaccine preparation, evaluation, and standardization; regulatory aspects; sera therapy; marketed products; challenges and newer approaches. | 9 Hours |
Recommended References
- Crommelin, D. J. A., Sindelar, R. D. and Meibohm, B. Pharmaceutical Biotechnology: Fundamentals and Applications. Springer.
- Walsh, G. Biopharmaceuticals: Biochemistry and Biotechnology. Wiley-Blackwell.
- Brown, T. A. Gene Cloning and DNA Analysis: An Introduction. Wiley-Blackwell.
- Glick, B. R., Pasternak, J. J. and Patten, C. L. Molecular Biotechnology: Principles and Applications of Recombinant DNA. ASM Press.
- Doran, P. M. Bioprocess Engineering Principles. Academic Press.
- Vogel, H. C. and Todaro, C. L. Fermentation and Biochemical Engineering Handbook. William Andrew.
- Primrose, S. B., Twyman, R. M. and Old, R. W. Principles of Gene Manipulation and Genomics. Wiley-Blackwell.
- Strachan, T. and Read, A. Human Molecular Genetics. Garland Science.
- Plotkin, S. A., Orenstein, W. A., Offit, P. A. and Edwards, K. M. Elsevier.
- Kindt, T. J., Goldsby, R. A., Osborne, B. A. and Kuby, J. Kuby Immunology. W. H. Freeman.
- Janeway, C. A., Travers, P., Walport, M. and Shlomchik, M. Immunobiology. Garland Science. Semester-IV
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