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AKTU Genetics and Molecular Biology (BBT402) Syllabus PDF – B.Tech 2nd Year
Genetics and Molecular Biology BBT402
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Official AKTU syllabus of Genetics and Molecular Biology (BBT402) for B.Tech 2nd Year – 4 credits, L-T-P 3-1-0. Read the unit-wise course content, course outcomes, evaluation pattern and recommended books online, or download the PDF.
Syllabus — Genetics and Molecular Biology
Download PDFBBT402 · 4 credits · L-T-P 3-1-0
Course Outcomes
| CO | Course Outcome |
|---|---|
| CO 1 | Understand the fundamental principles of genetics. |
| CO 2 | Understand genome organization in prokaryotes and eukaryotes as well as genome organization of cellular components. |
| CO 3 | Discuss the process of DNA replication & different repair mechanisms. |
| CO 4 | Comprehend mutation, its causes and translation in detail. |
| CO 5 | Discuss translation, recombinant DNA technology and enzymes involved in this process. |
Detailed Syllabus
| Unit | Topic | Proposed Lectures |
|---|---|---|
| I | Fundamental principles of genetics, gene interaction, multiple alleles, complementation, linkage, recombination and linkage mapping, extra-chromosomal inheritance, chromosomes basis of heredity, Sex determination, sex linked, sex limited and sex, influenced inheritance. | 08 |
| II | Genome organization: Genome organization in prokaryotes and eukaryotes - special features of eukaryotic gene structure and organization, genome organization in mitochondria and chloroplast, DNA content and C-value paradox. Methods to measure DNA content variation - Various types of DNA sequences (simple sequences, repetitive sequences, nonsense sequences, tandem gene clusters, satellites). | 08 |
| III | Gene structure, DNA & RNA as a genetic material, packaging of DNA as chromosome, central dogma of molecular biology, DNA replication, DNA repair. Linkage and recombination, crossing over and genetic mapping, gene mapping by two point and three point test crosses, Cell cycle regulation and apoptosis. | 08 |
| IV | Genetic mutation, micro-deletion, Genetic syndrome, Techniques to detect mutation, Transcription in prokaryotes and eukaryotes, genetic code, reverse transcription, MRNA processing. Role of sigma factor in transcription, role of promoters and enhancers, mechanism and regulation of transcription in prokaryotes and eukaryotes. | 08 |
| V | DNA replication process in prokaryotes & Eukaryotes, Activity of DNA polymerases and topoisomerases, Reverse transcriptase, Translation in prokaryotes and eukaryotes Basic principles of gene cloning and r-DNA technology, genetic code, properties of genetic code, wobble hypothesis, Molecular chaperones. | 08 |
Text Books
- Genetics a conceptual approach, 2nd Edition Benjamin A. Pierc WH freeman and, company, New York.
- Benjamin Levin — Genes VIII, 8 th ed. Bioprocess Engineering Principles — P. M. Doran, 5th ed.
- Albert B, Bray Denis et al.: Molecular Biology of The Cell, latest ed.
- Watson, Hopkins, Roberts et al.: Molecular Biology of the Gene, 4 th ed.
- Genetics- Strickberger, 2nd.
- Baltimore- Molecular Biology of the Cell.
- Advance Genetics by G.S. Miglani, Narosa Publishing House.
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