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AKTU Applied Chemistry for Biomolecules and Bioprocess Systems (AAS102F / AAS202F) Syllabus PDF – B.Tech 1st Year
Applied Chemistry for Biomolecules and Bioprocess Systems AAS102F / AAS202F
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Official AKTU syllabus of Applied Chemistry for Biomolecules and Bioprocess Systems (AAS102F / AAS202F) for B.Tech 1st Year – 3 credits, L-T-P 3-0-0. Read the unit-wise course content, course outcomes, evaluation pattern and recommended books online, or download the PDF.
Syllabus — Applied Chemistry for Biomolecules and Bioprocess Systems
Download PDFAAS102F / AAS202F · 3 credits · L-T-P 3-0-0
Course Objectives
- To understand the chemical structure and function of biomolecules including carbohydrates, proteins, lipids, and nucleic acids
- To apply thermodynamic and kinetic principles to analyze biochemical reactions and metabolic pathways
- To study the chemistry of enzymes, enzyme kinetics, and their applications in bioprocessing
- To analyze the chemistry of fermentation media, bioreactor systems, and downstream processing
- To introduce the chemistry of biopharmaceuticals, biosensors, and green biotechnology applications
Course Content
| Unit | Description | Weightage |
|---|---|---|
| 1. | Chemistry of Biomolecules: Structure and classification of carbohydrates (mono-, di-, polysaccharides), proteins (primary to quaternary structure, amino acid chemistry), lipids (fatty acids, phospholipids, sterols), nucleic acids (DNA and RNA structure, nucleotide chemistry), vitamins and coenzymes, biomolecular interactions and forces (hydrogen bonds, hydrophobic interactions, Van der Waals) | 20% |
| 2. | Biochemical Thermodynamics and Kinetics: Laws of thermodynamics applied to biological systems, Gibbs free energy, ATP as energy currency, coupled reactions, chemical equilibrium in biochemical systems, reaction kinetics (first and second order), activation energy, Arrhenius equation, transition state theory, introduction to enzyme catalysis and factors affecting enzyme activity. | 20% |
| 3. | Enzyme Chemistry and Bioprocess Applications: Classification and nomenclature of enzymes, active site chemistry, mechanisms of enzyme action, Michaelis-Menten kinetics, Km and Vmax, enzyme inhibition (competitive, non-competitive, uncompetitive), allosteric regulation, immobilized enzymes, industrial enzymes (proteases, amylases, lipases, cellulases), enzyme engineering | 20% |
| 4. | Fermentation Chemistry and Bioprocessing: Introduction to fermentation technology,Chemistry of fermentation media (carbon sources, nitrogen sources, minerals, growth factors), sterilization chemistry, aerobic and anaerobic fermentation, metabolic pathways (glycolysis, TCA cycle, pentose phosphate), yield coefficients, downstream processing (precipitation, chromatography, membrane filtration), product recovery | 20% |
| 5. | Biopharmaceuticals and Green Biotechnology: Chemistry of monoclonal antibodies, recombinant proteins, vaccines, nucleic acid therapeutics (siRNA, mRNA), biosimilars, drug formulation chemistry, biosensor chemistry (enzyme biosensors, immunosensors), bioremediation chemistry, Synthesis of typical organic compounds by conventional and Green route (Paracetamol), Environmental impact of Green chemistry on society. | 20% |
Teaching-Learning Methodology
Topics are taught through interactive lectures using blackboard and ICT tools. Laboratory demonstrations on enzyme kinetics, fermentation, and biomolecule characterization are included. Case studies on biopharmaceutical manufacturing and green bioprocessing supplement theoretical content.
Course Outcomes
| COs | Course Outcome Statement | KL |
|---|---|---|
| CO1 | Understand the chemical structure and functional significance of biomolecules | K2 |
| CO2 | Apply thermodynamic and kinetic principles to analyze biochemical reactions and metabolic processes | K3 |
| CO3 | Understand enzyme kinetics and apply enzyme chemistry to industrial bioprocess design | K3 |
| CO4 | Understand fermentation chemistry and apply it to bioprocess media design and product recovery | K3 |
| CO5 | Apply chemistry of biopharmaceuticals, biosensors, and green biotechnology to real-world applications | K3 |
Evaluation Pattern
| Sr. | Details of the Evaluation | Weightage |
|---|---|---|
| 1. | Internal Assessment (CT + Assignment + Quiz + Attendance) | 30% |
| 2. | External Assessment | 70% |
Text Books
- Engineering Chemistry – Jain and Jain
- Biochemistry – Lehninger, Nelson, and Cox
- Bioprocess Engineering Principles – Pauline M. Doran
- Enzyme Biochemistry – T. Palmer
- Industrial Biotechnology – Wittrup and Verdine (Eds.)
Online Resources
- NPTEL courses on Biochemistry and Bioprocess Engineering
- Coursera – Biochemistry specializations (Duke, Johns Hopkins)
- NCBI and UniProt online biochemical databases and resources
Additional References
Relevant review articles, research papers, and handouts on latest developments in:
- mRNA Therapeutics: Chemistry and Formulation
- Metabolic Engineering for Bio-based Chemical Production
- Bioremediation: Chemical and Microbiological Approaches
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