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AKTU SYSTEMIC PHARMACOLOGY II (Practical) (BP510P) Syllabus PDF – B.Pharm 5th Semester
SYSTEMIC PHARMACOLOGY II (Practical) BP510P
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Official AKTU syllabus of SYSTEMIC PHARMACOLOGY II (Practical) (BP510P) for B.Pharm 5th Semester – 2 credits, L-T-P 0-0-4. Read the unit-wise course content, course outcomes, evaluation pattern and recommended books online, or download the PDF.
Syllabus — SYSTEMIC PHARMACOLOGY II (Practical)
Download PDFBP510P · 2 credits · L-T-P 0-0-4
Course Objectives
- Provide understanding of the theoretical and practical aspects of different pharmacological experiments using virtual simulations and video demonstrations.
- Develop skills to assess drug effects on various systems such as cardiovascular, respiratory, skeletal muscle, and gastrointestinal using simulation models. 3. preparation, spasmogenic and spasmolytic effects, and PA2 value determination using Schild plot.
- Provide knowledge of the modern techniques for drug evaluation, such as intraocular pressure measurement, nitric oxide estimation, neutrophil function tests and spirometry.
- Explore clinical pharmacology aspects through case studies on drug interactions, management of cardiovascular and respiratory diseases, and plasma volume expanders.
Course Outcomes
| CO | Upon successful completion of this course, the students will be able to: |
| No. | |
| 1 | Explain the pharmacological principles and mechanisms of drug action involved in analgesic, antiepileptic, antidepressant, antipsychotic, antianxiety, and antiulcer drugs using interactive computer-based experimental models. |
| 2 | Apply experimental and simulation-based methods to evaluate drug activity using models such as Eddie's hot plate, MES-induced seizures, tail suspension test, elevated plus maze, actophotometer, Morris water maze, and ulcer models. |
| 3 | Analyse and interpret experimental pharmacological data, including bioassay results, dose-response relationships, and estimation of agonist/antagonist concentrations using 3-point/4-point bioassay, matching/bracketing methods, and hypothetical simulation datasets. |
| 4 | Demonstrate advanced biomedical and laboratory techniques, including cell culture methods, PCR for mRNA estimation, electrophoresis of DNA/proteins, and antibacterial sensitivity testing, relevant to pharmaceutical and biomedical research. |
| 5 | Utilize bioinformatics tools, open-source pharmacological databases, and network pharmacology software to predict drug targets, analyse ADME/toxicity profiles, and construct pharmacological networks. |
Course Content
List of practical (Minimum 12 experiments must be performed)
- Evaluation of analgesic activity of centrally and peripherally acting analgesics using Eddie's hot plate, tail-flick, tail immersion, and acetic acid-induced writhing methods through interactive computer simulation.
- Evaluation of antiepileptic activity using maximal electroconvulsive shock (MES)-induced seizures through interactive computer simulation.
- Demonstration of the antiepileptic activity using pentylenetetrazol-induced seizures through interactive computer simulation.
- Evaluation of antidepressant activity of drugs using the tail suspension test through interactive computer simulation.
- Demonstration and study of locomotor activity using actophotometer through interactive computer simulation.
- Evaluation of antianxiety activity using the elevated plus maze or zero maze model through interactive computer simulation.
- Evaluation of antipsychotic activity of drugs using inhibition of conditioned response on Cook's pole climbing apparatus through interactive computer simulation.
- Study of the effect of drugs on learning and memory using the Morris water maze test through interactive computer simulation.
- Study of antiulcer activity using indomethacin-induced or pylorus ligation-induced ulcer models.
- Estimation of the concentration of oxytocin on isolated rat uterus preparation using a suitable method through interactive computer-based simulation.
- Estimation of drug concentration by 3-point or 4-point bioassay through interactive computer simulation.
- Bioassay of histamine using matching, bracketing, or interpolation methods on suitable isolated tissue preparation with the help of interactive computer simulation.
- Study of cell culture techniques, including types of cell culture, laboratory instruments/equipment, culture media, and growth of cell cultures in laboratory facilities.
- Study of antibacterial sensitivity testing of urine culture using techniques such as the disc diffusion method (theoretical details/case studies).
- Demonstration using databases and software packages for predicting drug activity, ADME properties, and toxicity.
- Study of electrophoresis of protein and DNA samples and gel visualization techniques.
- Construction of pharmacological networks using predicted drug targets and disease genes with activity prediction databases, disease gene databases, and suitable software.
Recommended References
- Ghosh, M. N. Fundamentals of Experimental Pharmacology. Hilton & Company.
- Goyal, R. K. Practical Pharmacology. B. S. Shah Prakashan.
- Kulkarni, S. K. Handbook of Experimental Pharmacology. Vallabh Prakashan. Semester VI
| Course Code | Name of the Course | No. of hours per week (L/P) | Continuous Mode (Marks) | Sessional Exam (Marks) | Sessional Duration | Internal Total | End Semester Marks | Exam Duration | Total Marks Credit Points |
| BP601T | Advanced Pharmacognosy (Theory) | 3 | 15 | 1 Hr | 30 | 45 | 2 Hr | 75 | 3 |
| BP602T | Biopharmaceutics and Pharmacokinetics (Theory) | 3 | 15 | 1 Hr | 30 | 45 | 2 Hr | 75 | 3 |
| BP603T | Intellectual Property Rights (Theory) | 2 | 10 | 1 Hr | 20 | 30 | 1.5 Hr | 50 | 2 |
| BP604T | AI Applications in Pharmaceutical Sciences (Theory) | 2 | 10 | 1 Hr | 20 | 30 | 1.5 Hr | 50 | 2 |
| BP605T | Pharmaceutical Analysis (Theory) | 3 | 15 | 1 Hr | 30 | 45 | 2 Hr | 75 | 3 |
| BP606T | Pharmaceutical Jurisprudence (Theory) | 3 | 15 | 1 Hr | 30 | 45 | 2 Hr | 75 | 3 |
| BP607T | AEC* – Elective 3 (Theory) | 1 | 10 | 1 Hr | 20 | 30 | 1.5 Hr | 50 | 1 |
| BP608P | Biopharmaceutics and Pharmacokinetics (Practical) | 3 | 10 | 0 | 3 Hr | 20 | 30 | 3 Hr | 50 1 |
| BP609P | Pharmaceutical Analysis (Practical) | 4 | 10 | 4 Hr | 20 | 30 | 4 Hr | 50 | 2 |
| BP610P | SEC* – Elective 4 (Practical) | 2 | 10 | 3 Hr | 20 | 30 | 3 Hr | 50 | 1 |
| BP611P | VAC* – Elective 5 (Practical) | 2 | 10 | 3 Hr | 20 | 30 | 3 Hr | 50 | 1 |
| BP612I | Internship (Mandatory) | 8 | Refer Section 22 of the ordinance | – | 100 | 4 Hr | 100 | 4 | |
| Total | 28 | 130 | 20 Hr | 260 | 490 | 29.5 Hr | 750 | 26 |
* Only 1 course shall be selected from each elective
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