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AKTU Biomedicinal Chemistry (Theory) (BP501T) Syllabus PDF – B.Pharm 5th Semester
Biomedicinal Chemistry (Theory) BP501T
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Official AKTU syllabus of Biomedicinal Chemistry (Theory) (BP501T) for B.Pharm 5th Semester – 3 credits, L-T-P 3-0-0. Read the unit-wise course content, course outcomes, evaluation pattern and recommended books online, or download the PDF.
Syllabus — Biomedicinal Chemistry (Theory)
Download PDFBP501T · 3 credits · L-T-P 3-0-0
Course Objectives
- Provide comprehensive knowledge of drugs acting on the central nervous system, including anesthetics, sedatives, antipsychotics, and anticonvulsants, with emphasis on their chemical classification and structure activity relationships (SAR).
- Familiarize students with anti-infective chemotherapeutic agents used against tuberculosis, malaria, protozoal, viral, fungal, helminthic, and urinary tract infections, including their chemical structures and SAR.
- Impart understanding of antibiotics and sulfa drugs, focusing on their chemical classes, mechanisms, therapeutic relevance, and structure activity relationships.
- Introduce antineoplastic agents and endocrine drugs, highlighting their chemical nature, classification, therapeutic applications, and structure activity correlations.
- Develop knowledge of antidiabetic agents and narcotic analgesics, including opioid antagonists, with emphasis on medicinal chemistry principles and SAR of key drug classes.
Course Outcomes
| CO | Upon successful completion of this course, the students will be able to: |
| No. | |
| 1 | Classify and explain the chemistry, therapeutic use, and structure activity relationships of drugs acting on the central nervous system, including anesthetics, sedatives, antipsychotics, and anticonvulsants. |
| 2 | Describe the chemical classification, mechanism of action, and SAR of major anti-infective agents such as antituberculars, antimalarials, antivirals, antifungals, anthelmintics, and urinary tract anti-infectives. |
| 3 | Analyze the chemistry and SAR of antibiotics and sulfonamides and correlate structural features with antimicrobial activity and spectrum of action. |
| 4 | Explain the chemical basis, therapeutic significance, and SAR of antineoplastic agents and endocrine drugs used in cancer and hormonal disorders. |
| 5 | Interpret the chemistry, pharmacological relevance, and SAR of antidiabetic agents and narcotic analgesics, including opioid agonists and antagonists, for rational drug use and development. |
Course Content
| Unit No. | Topics Lectures Study of the development of the following classes of drugs includes chemical classification, structure, uses, SAR of selective drug classes, and synthesis of selected drugs as superscripted* | No. of |
| I | Drugs Acting on the Central Nervous System General Anesthetics Halothane, Methoxyflurane, Enflurane, Sevoflurane, Isoflurane, Desflurane, Methohexital, Thiamylal, Thiopental, Ketamine*, Ramelteon, Remimazolam, Fospropofol, Dexmedetomidine Sedatives and Hypnotics Barbital, Phenobarbital*, Mephobarbital, Amobarbital, Butabarbital, Pentobarbital, Secobarbital, Chlordiazepoxide, Diazepam*, Oxazepam, Chlorazepate, Lorazepam, Alprazolam, Zolpidem, Glutethimide, Meprobamate, Ethchlorvynol, Triclofos, Paraldehyde SAR of Barbiturates and Benzodiazepines Antipsychotics Promazine, Chlorpromazine*, Triflupromazine, Thioridazine, Piperacetazine, Prochlorperazine, Trifluoperazine, Chlorprothixene, Thiothixene, Loxapine, Clozapine, Haloperidol, Droperidol, Risperidone, Molindone, Sulpiride, Brexpiprazole, Lumateperone, Pimavanserin, Samidorphan SAR of Phenothiazines Anticonvulsants Phenobarbitone, Methabarbital, Phenytoin*, Mephenytoin, Ethotoin, Oxazolidinediones: Trimethadione, Paramethadione Succinimides: Phensuximide, Methsuximide, Ethosuximide Phenacemide, Carbamazepine*, Clonazepam, Primidone, Valproic acid, Gabapentin, Felbamate, Perampanel, Lacosamide, Retigabine SAR of Anticonvulsants | 10 Hours |
| II | Anti-Infective Chemotherapeutic Agents Antitubercular Agents Isoniazid*, Ethionamide, Ethambutol, Pyrazinamide, Para-amino salicylic acid*, Rifampicin, Rifabutin, Cycloserine, Streptomycin, Capreomycin, Pretomanid, Clofazimine, Levofloxacin, Bedaquiline, Linezolid, Delamanid Antimalarials Quinine, Chloroquine*, Amodiaquine, Primaquine, Pamaquine, Quinacrine, Mefloquine, Cycloguanil pamoate, Proguanil, Pyrimethamine, Artesunate, Artemether, Atovaquone SAR of Quinoline derivatives Antiprotozoals Metronidazole*, Tinidazole, Ornidazole, Diloxanide, Iodoquinol, Pentamidine isethionate, Atovaquone,Eflornithine, Paromomycin, Nitazoxanide Antivirals Amantadine, Rimantadine, Idoxuridine, Acyclovir*, Ganciclovir, Zidovudine, Didanosine, Zalcitabine, Lamivudine,Loviride, Delavirdine, Ribavirin, Saquinavir, Indinavir, Ritonavir, Valganciclovir, Peramivir, Lenacapavir Antifungals Amphotericin-B, Nystatin, Natamycin, Griseofulvin, Clotrimazole, Econazole, Butoconazole, Oxiconazole, Tioconazole, Miconazole, Ketoconazole*, Terconazole, Itraconazole, Fluconazole, Naftifine, Tolnaftate, Posaconazole, Isavuconazole Anthelmintics Diethylcarbamazine, Thiabendazole, Mebendazole, Albendazole*, Niclosamide, Oxamniquine, Praziquantel, Ivermectin Urinary Tract Anti-infective Agents Nalidixic acid, Norfloxacin, Enoxacin, Ciprofloxacin*, Ofloxacin, Lomefloxacin, Sparfloxacin, Gatifloxacin, Furazolidone, Nitrofurantoin, Methenamine, Moxifloxacin SAR of Quinolones | 12 Hours |
| III | Antibiotics and Sulfa Drugs Antibiotics -Lactamase inhibitors, Monobactams Aminoglycosides: Streptomycin, Neomycin, Kanamycin, Tetracyclines: Tetracycline, Oxytetracycline, Minocycline, Doxycycline, Macrolides: Erythromycin, Clarithromycin, Azithromycin Chloramphenicol*, Clindamycin, Clavulanic acid SAR of Penicillins, Tetracyclines, and Cephalosporins Sulfa Drugs Sulphamethizole, Sulfisoxazole, Sulphapyridine, Sulphathiazole, Sulfacetamide, Sulphamethoxazole,Sulphadiazine, Mefenide, Sulfasalazine, Trimethoprim, Cotrimoxazole, Dapsone* SAR of Sulfonamides | 8 Hours |
| IV | Antineoplastic Agents Mechlorethamine, Cyclophosphamide, Melphalan, Chlorambucil, Busulfan, Thiotepa, Mercaptopurine*, Thioguanine, Fluorouracil, Floxuridine, Cytarabine, Methotrexate*, Azathioprine, Dactinomycin, Daunorubicin, Doxorubicin, Bleomycin, Etoposide, Vinblastine, Vincristine, Paclitaxel, Camptothecin, Cisplatin, Mitotane, Carboplatin | 6 Hours |
| V | Endocrine Drugs, Antidiabetic Agents and Narcotic Analgesics Endocrine Drugs Sex hormones: Testosterone, Nandrolone, Progesterone, Oestriol, Oestradiol, Oestrone, Diethylstilbestrol Drugs for erectile dysfunction: Sildenafil, Tadalafil Oral contraceptives: Mifepristone, Norgestrel, Levonorgestrel Corticosteroids: Cortisone, Hydrocortisone, Prednisolone, Betamethasone, Dexamethasone Thyroid and antithyroid drugs: L-Thyroxine, L-Thyronine, Propylthiouracil, Methimazole Antidiabetic Agents Insulin and preparations, Tolbutamide*, Chlorpropamide, Glipizide, Glimepiride Biguanides: Metformin Thiazolidinediones: Pioglitazone, Rosiglitazone Repaglinide, Nateglinide, Acarbose, Voglibose Narcotic Analgesics Morphine, Codeine, Meperidine, Anilerdine, Diphenoxylate, Loperamide, Fentanyl*, Methadone, Propoxyphene, Pentazocine, Levorphanol Nalorphine, Levallorphan, Naloxone SAR of Morphine analogues | 9 Hours |
Recommended References
- Abraham, D. J. and Griffin, J. L. Wiley.
- Brunton, L., Hilal-Dandan, R. and Knollmann, B. Pharmacological Basis of Therapeutics. McGraw-Hill Education.
- Kar, Ashuthosh. Medicinal Chemistry. New Age International.
- Lednicer, D. The Organic Chemistry of Drug Synthesis. Wiley.
- Li, J. J. Modern Drug Synthesis. Wiley.
- Patrick, G. L. An Introduction to Medicinal Chemistry. Oxford University Press.
- Vogel, A. I. Pearson Education.
- Williams, D. A., Lemke, T. L. and Roche, V. F. Lippincott Williams & Wilkins.
- Wilson, C. O., Beale, J. M. and Block, J. H. Medicinal and Pharmaceutical Chemistry. Lippincott Williams & Wilkins.
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