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AKTU Pharmaceutical Analysis (Theory) (BP605T) Syllabus PDF – B.Pharm 6th Semester
Pharmaceutical Analysis (Theory) BP605T
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Official AKTU syllabus of Pharmaceutical Analysis (Theory) (BP605T) for B.Pharm 6th Semester – 3 credits, L-T-P 3-0-0. Read the unit-wise course content, course outcomes, evaluation pattern and recommended books online, or download the PDF.
Syllabus — Pharmaceutical Analysis (Theory)
Download PDFBP605T · 3 credits · L-T-P 3-0-0
Course Objectives
- Understand the interaction of matter with electromagnetic radiation and its application in spectroscopic methods for pharmaceutical drug analysis.
- Study the principles, instrumentation, and pharmaceutical applications of electroanalytical techniques such as potentiometry, conductometry, polarography, and amperometry.
- Understand and apply various chromatographic and electrophoretic separation techniques used for qualitative and quantitative analysis of drugs.
- Impart knowledge of instrumental methods used for accurate qualitative and quantitative analysis of pharmaceutical substances.
- Develop the ability to select, optimize, and validate suitable analytical techniques, interpret analytical data.
Course Outcomes
| CO | Upon successful completion of this course, the students will be able to: |
| No. | |
| 1 | Explain the theoretical basis of electrochemical methods (potentiometry, conductometry, polarography, amperometry) and spectroscopic techniques (UV- Visible, IR, fluorometry, atomic absorption). |
| 2 | Explain the instruments involved in electroanalytical and spectroscopic methods. |
| 3 | Describe the principles, instrumentation, and applications of various chromatographic and electrophoretic techniques. |
| 4 | Select suitable analytical techniques for specific pharmaceutical analysis requirements. |
| 5 | Analyze, interpret, and report analytical data accurately and draw meaningful conclusions. |
Course Content
| Unit | Topics | No. of |
|---|---|---|
| I | Electrochemical Methods of analysis 1. Potentiometry: Electrode potential, electrochemical cell, construction and working of reference and indicator electrodes including membrane electrodes, measurement of potential and pH, potentiometric titrations, methods of detecting end point and Karl Fischer titration. 2. Conductometry: Introduction, conductivity cell, conductometric titrations and applications. 3. Polarography: Introduction, residual current, migration current, diffusion current and limiting current, DME, applications. | 10 hours |
| II | Spectroscopy 1. Fundamentals of Spectroscopy: Properties of electromagnetic radiation, electromagnetic spectrum. 2. UV Visible spectroscopy: and deviations. Electronic transitions, chromophores, auxochromes, spectral shifts, solvent effect on absorption spectra, Instrumentation - Sources of radiation, wavelength selectors, sample cells, detectors (Photo tube, Photomultiplier tube, Photo voltaic cell, Silicon Photodiode). Applications - single and multi-component analysis of pharmaceuticals. 3. IR spectroscopy: Introduction, fundamental modes of vibrations in poly atomic molecules, factors affecting vibrations, Instrumentation of dispersive Infrared spectrophotometer (including sample handling Techniques) and FTIR. Pharmaceutical applications. | 10 hours |
| III | Fluorometric Analysis 1. Theory, luminescence, factors affecting fluorescence, quenching. Instrumentation and pharmaceutical applications. 2. Flame Photometry and Atomic Absorption Spectrometry: Theory, nebulisation, flame and flame temperature, interferences, instrumentation and pharmaceutical applications. 3. Nepheloturbidometry: Principle, instrumentation and applications. | 7 hours |
| IV | Introduction to Chromatographic Techniques 1. Principle, various stationary and mobile phases, diverse development and detection techniques and applications of column, paper and thin layer chromatography. 2. Ion-exchange chromatography: Introduction, principles, types of ions exchange resins, factors affecting ion exchange, methodology and applications. 3. Gel filtration and affinity chromatography: Principles and applications. 4. Electrophoresis: Introduction, factors affecting electrophoretic mobility, Techniques of paper, gel, capillary electrophoresis, applications. | 8 hours |
| V | 1. Gas chromatography: Introduction, theory, instrumentation, derivatization, temperature programming, advantages, disadvantages and applications 2. High performance liquid chromatography: Introduction, theory, instrumentation, advantages and applications. 3. HPTLC: Principle, instrumentation and applications. | 10 hours |
Recommended References
- Braun, R. D. Analytical Chemistry: A Modern Approach to Analytical Science. McGraw-Hill.
- Dyer, J. R. Applications of Absorption Spectroscopy of Organic Molecules. Prentice Hall.
- Harvey, D. Modern Analytical Chemistry. McGraw-Hill.
- Sharma, Y. R. Organic Spectroscopy. S. Chand.
- Skoog, D. A., Holler, F. J. and Crouch, S. R. Principles of Instrumental Analysis. Cengage Learning.
- Watson, D. G. Pharmaceutical Analysis. Elsevier.
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