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AKTU Advanced Pharmacognosy (Theory) (BP601T) Syllabus PDF – B.Pharm 6th Semester
Advanced Pharmacognosy (Theory) BP601T
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Official AKTU syllabus of Advanced Pharmacognosy (Theory) (BP601T) for B.Pharm 6th Semester – 3 credits, L-T-P 3-0-0. Read the unit-wise course content, course outcomes, evaluation pattern and recommended books online, or download the PDF.
Syllabus — Advanced Pharmacognosy (Theory)
Download PDFBP601T · 3 credits · L-T-P 3-0-0
Course Objectives
- Understand reverse pharmacology and integrative approaches in natural drug discovery.
- Apply metabolomics and systems biology tools for quality control and bioactivity evaluation of herbal medicines.
- Explore modern AI-driven, in-silico, and high-throughput techniques for identification and optimization of natural product leads.
- Study validation, safety, and development pathways of herbal leads including preclinical and clinical evaluation.
- Understand legal, ethical, and patenting frameworks related to bioprospecting, traditional knowledge protection, and natural product innovation.
Course Outcomes
| CO | Upon successful completion of this course, the students will be able to: |
| No. | |
| 1 | Explain reverse pharmacology, traditional knowledge databases, and bioprospecting strategies. |
| 2 | To analyze herbal drugs using metabolomics, spectral libraries, and chemoinformatics tools. |
| 3 | Employ modern in-silico and AI techniques in lead identification and optimization from natural products. |
| 4 | Evaluate preclinical safety, pharmacokinetics, and efficacy of bioactive leads. |
| 5 | Interpret global IP frameworks and develop strategies for patenting herbal products and protecting traditional knowledge. |
Course Content
| Unit | Topics | No. of |
|---|---|---|
| I | Reverse Pharmacology and Integrative Approaches Reverse pharmacology and integrative approaches from the AYUSH perspective. Ethnopharmacological approach to bioprospecting. Traditional medicine databases: AYUSH Research Portal, ICMR Standards on Indian Medicinal Plants, TKDL, NAPRALERT, Super Natural, etc. Molecular docking and ADMET screening of bioactives. Concept of adjuvant therapy with herbals in metabolic and non-communicable diseases. | 6 hours |
| II | Metabolomics and Systems Biology Introduction to metabolomics and its tools: applications of NMR and HRMS in metabolomics, Metabolomics profiling and dereplication studies, Role of metabolomics in quality control, scientific, validation of traditional claims and pharmacological evaluation, Network pharmacology and systems biology approaches to herbal medicine, Significance of spectral libraries and chemoinformatics databases in drug discovery | 11 hours |
| III | Modern Techniques in Natural Product Discovery Role of artificial intelligence (AI), Machine learning and big data in Drug discovery from natural Products. Molecular docking, Virtual Screening and Pharmacophore modelling, Use of Genomic and transcriptomic tools in medicinal plant research, High-throughput screening (HTS) and bioautography. | 10 hours |
| IV | Validation and Development of Herbal Leads Bioactivity Guided Fractionation, characterization /Structure Elucidation, Optimization of lead compounds for better efficacy, safety, and stability through SAR and QSAR modelling for semi-synthetic compounds of Salicin, Artemisinin, Piperine, Papaverine and Andrographolides. Preclinical, Clinical Evaluation and New Drug approvals: Testing for toxicity as per OECD guidelines, pharmacokinetics, and bioavailability of herbal products, extracts and lead compounds, assessment of safety and efficacy, clinical trials with or without placebo for clinical endpoints based on assessment of quality of life reporting adverse events if any, filing IND application, NDA submission, Regulatory review and post marketing surveillance. | 12 hours |
| V | Patenting of Natural Products Key Terminologies and Concepts: Definitions and distinctions: Patent, Intellectual Property Rights (IPR) Farmers' Rights and Breeders' Rights, Bioprospecting and Biopiracy Patenting Aspects of Natural Products and Traditional Knowledge: Legal frameworks and challenges in patenting natural substances, Traditional Knowledge Digital Library (TKDL) and its role in protecting indigenous knowledge. Role of National Biodiversity Authority in patenting natural products and NAGOYA protocol. Case Studies: Turmeric U.S. patent on wound healing and its revocation, Neem Biopiracy issue and patent cancellation. | 6 hours |
Recommended References
- Bhat, S. V., Nagasampagi, B. A. and Sivakumar, M. Chemistry of Natural Products. Springer.
- Gräbley, S. and Thiericke, R. Drug Discovery from Nature. Springer.
- Hanessian, S. Natural Products in Medicinal Chemistry. Wiley-VCH.
- Ikan, R. Natural Products: A Laboratory Guide. Academic Press.
- Kemp, W. Spectroscopic Methods in Organic Chemistry. Macmillan.
- Narayanan, P. Intellectual Property Law. Eastern Law House.
- Sarker, S. D., Latif, Z. and Gray, A. I. Natural Products: Isolation, Structure Elucidation and History. Elsevier.
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