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AKTU Pharmaceutical Organic Chemistry (Theory) (BP204T) Syllabus PDF – B.Pharm 2nd Semester
Pharmaceutical Organic Chemistry (Theory) BP204T
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Official AKTU syllabus of Pharmaceutical Organic Chemistry (Theory) (BP204T) for B.Pharm 2nd Semester – 4 credits, L-T-P 4-0-0. Read the unit-wise course content, course outcomes, evaluation pattern and recommended books online, or download the PDF.
Syllabus — Pharmaceutical Organic Chemistry (Theory)
Download PDFBP204T · 4 credits · L-T-P 4-0-0
Course Objectives
- Develop a clear understanding of the chemistry of saturated hydrocarbons.
- Study the chemistry and reactions of unsaturated hydrocarbons.
- Understand the chemistry and reaction mechanisms of alkyl halides.
- Explain the chemistry of aromatic hydrocarbons and their derivatives.
- Provide an understanding of carbonyl compounds and fundamental organic reaction mechanisms relevant to pharmaceuticals.
Course Outcomes
| CO | Upon successful completion of this course, the students will be able to: |
| No. | |
| 1 | Describe the chemical reactions and mechanisms of aliphatic saturated hydrocarbons. |
| 2 | Explain the reactions and mechanisms of aliphatic unsaturated hydrocarbons. |
| 3 | Understand nucleophilic substitution and elimination reactions of alkyl halides. |
| 4 | Explain electrophilic aromatic substitution reactions and the effect of substituents. |
| 5 | Apply knowledge of carbonyl compounds and reaction mechanisms in pharmaceutical chemistry. |
Course Content
| Unit | Topics | No. of |
|---|---|---|
| I | Aliphatic Saturated Hydrocarbons Alkanes Clemmensen reduction, Wolff Kishner reduction Chemical reactions of alkanes Mechanism of free radical substitution (halogenation) Pharmaceutical applications of alkanes: Liquid paraffin, soft paraffin, hard paraffin Cycloalkanes Coulson Moffitt modification Sachse Mohr theory | 12 |
| II | Aliphatic Unsaturated Hydrocarbons - Alkenes Methods of preparation: o Dehydration of alcohols o Dehydrohalogenation of alkyl halides o Dehalogenation of vicinal dihalides o Wittig reaction Chemical reactions of alkenes Mechanism of electrophilic addition reactions - Ozonolysis Conjugated Dienes Stability of conjugated dienes Mechanism of Diels Alder reaction Electrophilic and free radical addition reactions 1,2- and 1,4-addition reactions | 12 |
| III | Alkyl Halides Nucleophilic substitution reactions: SN1 and SN2 o Mechanism, kinetics, substrate structure, solvent effect, stereochemistry Elimination reactions: E1 and E2 o Mechanism, kinetics, substrate structure, solvent effect, stereochemistry Comparison of substitution vs elimination reactions | 12 |
| IV | : Benzene and Its Derivatives - IUPAC nomenclature of mono- and di-substituted benzene derivatives Structure of benzene Molecular orbital picture and resonance Electrophilic aromatic substitution reactions: o Nitration o Halogenation o Friedel Crafts alkylation and its limitations o Friedel Crafts acylation o Sulphonation and desulphonation Effect of substituents on reactivity and orientation | 12 |
| V | Carbonyl Compounds - Aldehydes and Ketones Preparation and properties of carbonyl compounds Nucleophilic addition reactions Aldol condensation and crossed aldol condensation Cannizzaro and crossed Cannizzaro reactions Benzoin and Perkin condensation Oxidation and reduction reactions Pharmaceutical applications of carbonyl compounds: Chloral, Paraldehyde, Ketoprofen | 12 |
Recommended References
- Morrison, R.T., Boyd, R.N. and Bhattacharjee, S.K., Organic Chemistry. Pearson Education India.
- Finar, I.L., Organic Chemistry, Vol. I. Pearson Books.
- Bahl, B.S. and Bahl, A., Textbook of Organic Chemistry. S. Chand & Company.
- Furniss, B.S., .
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