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AKTU Modern Analytical Techniques (Theory) (BP704T) Syllabus PDF – B.Pharm 7th Semester
Modern Analytical Techniques (Theory) BP704T
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Official AKTU syllabus of Modern Analytical Techniques (Theory) (BP704T) for B.Pharm 7th Semester – 3 credits, L-T-P 3-0-0. Read the unit-wise course content, course outcomes, evaluation pattern and recommended books online, or download the PDF.
Syllabus — Modern Analytical Techniques (Theory)
Download PDFBP704T · 3 credits · L-T-P 3-0-0
Course Objectives
- Introduce advanced instrumental techniques used in pharmaceutical analysis,.
- Provide conceptual understanding of modern separation and hyphenated analytical techniques.
- Familiarize students with principles and applications of green analytical chemistry and sustainable analytical method development.
- Explain the fundamentals of bioanalytical methods and immunoassays.
- Introduce microscopy-based analytical techniques and highlight their role in structural characterization and pharmaceutical research.
Course Outcomes
| CO | Upon successful completion of this course, the students will be able to: |
| No. | |
| 1 | Apply the principle of Mass and NMR spectra in the structural elucidation of organic compounds. |
| 2 | Determine the physical nature of the drugs and excipients using thermal studies, X ray crystallographic techniques and microscopy based analytical techniques. |
| 3 Apply the basic knowledge on radio immune assays in carrying out the immunological studies. | |
| 4 | Chromatographic techniques used for analysis of drugs. |
| 5 | Apply green analytical chemistry techniques for environmental sustainability. |
Course Content
| Unit | Topics | No. of |
|---|---|---|
| I | 1. Nuclear Magnetic Resonance Spectroscopy: Principles of ¹H-NMR and ¹³C-NMR, various solvents used, chemical shift, factors affecting chemical shift, coupling constant, spin spin coupling, relaxation, instrumentation of FT-NMR and its applications. 2. Mass Spectrometry: Principles, fragmentation and its rules, ionization techniques | 10 hour |
Electron impact, chemical ionization, MALDI, FAB, API, analyzers Time of flight and quadrupole, ion trap, detectors and applications.
| II | 1. X-Ray Diffraction Methods: Origin of X-Rays, basic aspects of crystals, X-Ray crystallography, rotating crystal technique, single crystal diffraction, powder diffraction, structural elucidation and applications. 2. Thermal Analysis: Introduction, instrumentation, factors affecting measurements, applications of TGA, DSC (types) and DTA. | 08 hour |
| III | 1. UPLC and Nano LC: Principle, advantages over LC and applications. 2. Principle and applications of hyphenated techniques: GC-MS, LC- MS/MS, ICP-MS. 3. Supercritical chromatography and flash chromatography: principles and applications. | 10 hour |
| IV | 1. Green Analytical Chemistry: Types of green solvents, various computational tools used to assess the greenness and its applications in sample preparation and analytical method development. 2. Bio-analytical Methods: Introduction to bioanalytical method development, extraction of drugs and metabolites from biological fluids SPE, LLE, PPE, BCS classification, PK-PD interaction, microsomal assays, MTT assay, BA & BE study protocol, biosimilars. 3. Radio Immune Assays and ELISA: Importance, various components, principle, different methods, limitations and applications of radio immunoassay and ELISA. | 12 hour |
| V | 1. Microscopy-Based Analytical Techniques: Principle, instrumentation, and applications of optical microscopy, scanning electron microscopy and transmission electron microscopy. | 5 hour |
Recommended References
- Brown, M. E. Introduction to Thermal Analysis: Techniques and Applications. Springer.
- Cullity, B. D. and Stock, S. R. Elements of X-Ray Diffraction. Prentice Hall.
- Dong, M. W. Modern HPLC for Practicing Scientists. Wiley.
- Friebolin, H. Basic One- and Two-Dimensional NMR Spectroscopy. Wiley.
- Niessen, W. M. A. Liquid Chromatography Mass Spectrometry. CRC Press.
- Poole, C. F. The Essence of Chromatography. Elsevier.
- Silverstein, R. M., Webster, F. X., Kiemle, D. J. and Bryce, D. L. Spectrometric Identification of Organic Compounds. Wiley.
- Skoog, D. A., Holler, F. J. and Crouch, S. R. Principles of Instrumental Analysis. Cengage Learning.
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